The reference site for Clorazepate

Clorazepate (marketed under the brand names Tranxene and Novo-Clopate), also known as clorazepate dipotassium, is a benzodiazepine. It possesses anxiolytic, anticonvulsant, sedative, hypnotic, and skeletal muscle relaxant properties.

WHAT IS Clorazepate?

Clorazepate is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It works by enhancing the effects of a certain natural chemical in the body (GABA).

Clorazepate is used to relieve anxiety, nervousness, and tension associated with anxiety disorders. This medicine is also used to reduce symptoms associated with alcohol withdrawal, and to treat certain types of seizures.

It is marketed under brand name Tranxene®, amongst others.

 

Brand Name(s): Cloraze Caps; Cloraze Tabs; GenENE;Tranxene; Tranxene-SD
CAS nº: 57109-90-7
(klor AH zeh pate)

 

Product Info

The sections below will provide you with more specific information and guidelines related to clorazepate and its correct use. Please read them carefully.

FDA Information

Clorazepate was approved for use in the United States by the Food and Drug Administration in 1972. A prescription is required for this medicine.

However, clorazepate has been discontinued since February 2006 in the UK.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Clorazepate is used to relieve anxiety, nervousness, and tension associated with anxiety disorders. Clorazepate is also used to reduce symptoms associated with alcohol withdrawal, and to treat certain types of seizures.

Clorazepate is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It works by enhancing the effects of a certain natural chemical in the body (GABA).

Other uses for this medicine

Clorazepate is also used to treat irritable bowel syndrome.

Nevertheless, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Clorazepate comes as a tablet and capsule which is to be taken by mouth. It is usually taken one to four times a day, with a full glass of water, and may be taken with or without food.

Take clorazepate exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Do not crush or chew the extended-release forms of clorazepate (Tranxene-SD® and Tranxene-SD® half strength). These tablets are specially formulated to release the medication slowly in the body.

It is important to note that clorazepate is habit forming. You can become physically and psychologically dependent on the medication. Do not take more than the prescribed amount of medication or take it for longer than is directed by your doctor. Withdrawal effects may occur if clorazepate is stopped suddenly after several weeks of continuous use. Your doctor may recommend a gradual reduction in dose.

What special precautions should I follow?

BEFORE TAKING CLORAZEPATE:

Please inform your doctor if you have kidney disease, liver disease, asthma, bronchitis, emphysema, or another respiratory disease, or are depressed or have suicidal thoughts. You may not be able to take clorazepate, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Also, antacids may decrease the effects of clorazepate. Separate doses of an antacid and clorazepate by several hours whenever possible.

Furthermore, cimetidine inhibits breakdown of clorazepate, and leads to increased levels of the drug in the system. Drugs other than those listed here may also interact with clorazepate. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Do not take clorazepate if you have narrow-angle glaucoma. Clorazepate may worsen this condition.

Clorazepate is in the FDA pregnancy category D. This means that clorazepate is known to harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant.

Additionally, it is not known whether clorazepate passes into breast milk. Do not take clorazepate without first talking to your doctor if you are breast-feeding a baby.

Use cautiously when driving, operating machinery, or performing other hazardous activities. Clorazepate will cause drowsiness and may cause dizziness. If you experience drowsiness or dizziness, avoid these activities.

Avoid alcohol while taking clorazepate. Alcohol may increase drowsiness and dizziness caused by clorazepate.

If you are over 65 years of age, you may be more likely to experience side effects from clorazepate. You may require a lower dose of this medication.

Clorazepate is not approved for use by children younger than 9 years of age.

What should I do if I forget a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose.

Never take a double dose of this medication. A double dose could be dangerous.

What side effects can this medication cause?

If you experience any of the following serious side effects, stop taking clorazepate and seek emergency medical attention or contact your doctor immediately:

an allergic reaction (difficulty breathing, closing of your throat, swelling of your lips, face, or tongue, or hives)
sores in the mouth or throat
yellowing of the skin or eyes
a rash
hallucinations or severe confusion
changes in vision

Other, less serious side effects may be more likely to occur. Continue to take clorazepate and talk to your doctor if you experience:

drowsiness, dizziness, or clumsiness
depression
nausea, vomiting, diarrhea, or constipation
difficulty urinating
vivid dreams
headache
dry mouth
decreased sex drive
changes in behavior

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Throw away any medication that is outdated or no longer needed and, if necessary, talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, please call the local emergency services immediately on 911.

Symptoms of overdose may include:

sleepiness
dizziness
confusion
a slow heart beat
difficulty breathing
difficulty walking and talking
an appearance of being drunk
unconsciousness

Product Images

PICTURES OF CLORAZEPATE PILLS

Below you will find images and specific information on the principal types of clorazepate that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: CLORAZEPATE
Strength(s): 3.75 MG
Imprint: M 30
Manufacturer: MYLAN

Name: CLORAZEPATE
Strength(s): 3.75 MG
Imprint: WATSON 363 | 3.75
Manufacturer: WATSON LABS.

Name: CLORAZEPATE
Strength(s): 3.75 MG
Imprint: WATSON | 835 3.75
Manufacturer: WATSON LABS.

Name: TRANXENE-T®
Strength(s): 3.75 MG
Imprint:  TL
Manufacturer: ABBOTT LABS.

Name: CLORAZEPATE
Strength(s): 7.5 MG
Imprint: AM
Manufacturer: ABLE LABS INC.

Name: CLORAZEPATE
Strength(s): 7.5 MG
Imprint: M 40
Manufacturer: MYLAN

Name: CLORAZEPATE
Strength(s): 7.5 MG
Imprint: WATSON 364 | 7.5
Manufacturer: WATSON LABS.

Name: CLORAZEPATE
Strength(s): 7.5 MG
Imprint: WATSON | 836 7.5
Manufacturer: WATSON LABS.

Name: TRANXENE-T®
Strength(s): 7.5 MG
Imprint: OV 32
Manufacturer: OVATION PHARM.

Name: TRANXENE-T®
Strength(s): 7.5 MG
Imprint: TM
Manufacturer: ABBOTT LABS.

Name: TRANXENE-SD®
Strength(s): 11.25 MG
Imprint: TX
Manufacturer: ABBOTT LABS.

Name: TRANXENE-SD®
Strength(s): 11.25 MG
Imprint: TX
Distributor: OVATION PHARM.

Name: CLORAZEPATE
Strength(s): 15 MG
Imprint: M 70
Manufacturer: MYLAN

Name: TRANXENE-T®
Strength(s): 15 MG
Imprint: TN
Manufacturer: ABBOTT LABS.

Name: TRANXENE-SD®
Strength(s): 22.5 MG
Imprint: TY
Manufacturer: ABBOTT LABS.

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